6-Ethoxy-2-benzothiazolesulfonamide

  • Cardrase
  • Diuretic C
  • Ethoxazolamide
  • Ethoxzolamide
  • Ethoxyzolamide
Formula
C9H10N2O3S2
Structure
Uses
A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.

Registry Numbers and Inventories.
CAS
452-35-7
EC (EINECS/ELINCS)
207-199-5
36/37/38 40
RTECS
DL6390000
RTECS class
Drug; Reproductive Effector
Merck
13,3790
Beilstein/Gmelin
212240
Beilstein Reference
4-27-00-04404

Properties.
Formula
C9H10N2O3S2
Formula mass
258.32
Melting point, °C
190 - 193
Boiling point, °C
465
Vapor pressure, mmHg
8E-9 (25 C)
Solubility in water
Insoluble
pKa/pKb
8.24 (pKa)
Heat of vaporization
72.6 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Flash Point,°C
235
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Transport.