6,7-Dimethoxycoumarin

  • Escoparone
  • 6,7-Dimethylesculetin
  • 6,7-Dimethoxybenzopyran-2-one
  • Scopoletin methyl ether
Formula
C11H10O4
Structure
Description
Off-white solid.
Uses
A specific constitutive androstane receptor activator that accounts for the therapeutic effect of the Chinese herbal tea Yin Zhi Huang in treating neonatal jaundice.

Registry Numbers and Inventories.
CAS
120-08-1
EC (EINECS/ELINCS)
204-369-0
RTECS
GN6550000
RTECS class
Drug; Reproductive Effector
Merck
12,8548
Beilstein/Gmelin
169572
Beilstein Reference
5-18-03-00204

Properties.
Formula
C11H10O4
Formula mass
206.2
Melting point, °C
145 - 146
Boiling point, °C
369
Vapor pressure, mmHg
1E-5 (25 C)
Solubility in water
Slightly soluble
Heat of vaporization
61.6 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Wear respirator, chemical safety goggles, rubber boots, and heavy rubber gloves.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, Strong bases.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Flash Point,°C
167
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful. Harmful if swallowed. Irritating to eyes.
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.