7,12-Dimethylbenz[a]anthracene

  • 9,10-Dimethyl-1,2-benzanthracene
Formula
C20H16
Structure
Description
Yellow to greenish-yellow crystals or a yellow solid. Odorless. Bluish-violet fluorescence in UV light.
Uses
In exptl medicine to induce various malignant tumors in testing antineoplastic drugs.

Registry Numbers and Inventories.
CAS
57-97-6
EC (EINECS/ELINCS)
200-359-5
RTECS
CW3850000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
2811
Merck
12,3285
Beilstein/Gmelin
1912135
Beilstein Reference
4-05-00-02587
RCRA
U094
Swiss Giftliste 1
G-4622
Canada DSL/NDSL
DSL
US TSCA
Listed

Properties.
Formula
C20H16
Formula mass
256.35
Melting point, °C
123
Boiling point, °C
440
Vapor pressure, mmHg
3E-8 (25 C)
Solubility in water
Insoluble
Partition coefficient, pKow
5.80
Heat of vaporization
69.7 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
227
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Material will burn in a fire. Use water spray to keep fire-exposed containers cool. Extinguishing media: Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire.
Fire potential
This chemical is combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Carcinogin
CP65
Poison_Class
1*
Exposure effects
In experimental animal studies, PAHs and metabolites cross the placenta. Female offspring of experimental animals exposed to PAHs during pregnancy have a decrease in the number of functional oocytes, sometimes such that they are infertile. <br>PAHs are lipophilic and are excreted in breast milk, allowing for secondary exposure of nursing infants, although the potential significance of such exposure has not been determined.
   Ingestion
Harmful if swallowed. The toxicological properties of this substance have not been fully investigated.
   Inhalation
The toxicological properties of this substance have not been fully investigated. Inhalation of dust may cause respiratory tract irritation.
   Skin
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
   Eyes
Dust may cause mechanical irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse. Remove contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
DLB