8-Methoxypsoralen

  • Methoxsalen
  • 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone
  • 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-Lactone
  • 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-methoxy
  • 8-Methoxy-(furano-3'.2':6.7-coumarin)
  • 9-Methoxyfuro[3,2-g]chromen-7-one
Formula
C12H8O4
Structure
Description
Odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation.
Uses
Suntan accelerator, sunburn protector.

Registry Numbers and Inventories.
CAS
298-81-7
EC (EINECS/ELINCS)
206-066-9
RTECS
LV1400000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector
UN (DOT)
2810
Merck
12,6068
Beilstein/Gmelin
196453
Beilstein Reference
5-19-06-00015
Swiss Giftliste 1
G-6208
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H8O4
Formula mass
216.19
Melting point, °C
147
Boiling point, °C
415
Vapor pressure, mmHg
4E-7 (25 C)
Density
1.539 g/cm3
Solubility in water
Slighty soluble
Partition coefficient, pKow
1.31
Heat of fusion
23.6 kJ/mol
Heat of vaporization
66. kJ/mol

Hazards and Protection.
Storage
Corrosives area. Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Store protected from light. Discard contaminated shoes.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures. May decompose when exposed to light.
Incompatibilities
Strong oxidizing agents, direct light.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
205
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Carcinogin
I-1, N-1, CP65
Poison_Class
4
Exposure effects
Effects may be delayed.
   Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May be harmful if swallowed. May cause systemic effects. May cause nausea, insomnia, nervousness, and depression. May cause liver damage in sufficient quantities.
   Inhalation
Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects.
   Skin
Causes skin burns. Contact with the skin may cause photosensitivity. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color. May cause erythema and blistering.
   Eyes
Causes eye burns. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
2810
Response guide
Hazard class
6.1
Packing Group
I; II; III