AEBSF hydrochloride

  • Pefabloc
  • Pefabloc SC
  • Pefabloc SC Plus
  • AEBSF
  • Benzenesulfonyl fluoride, p-(2-aminoethyl)-, hydrochloride
  • [4-(2-Aminoethyl)-benzenesulfonylfluoride hydrochloride
Formula
C8H10FNO2S.HCl
Structure
Description
White to off-white powder crystals.
Uses
Protease inhibitor.

Registry Numbers and Inventories.
CAS
30827-99-7
Beilstein/Gmelin
NA
New Zealand
Listed

Properties.
Formula
C8H11ClFNO2S
Formula mass
239.5
Melting point, °C
175 - 177
Solubility in water
10 g/L (20 C)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store at around 20 C.
Handling
Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Take precautionary measures against static discharges. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Provide ventilation.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride, chloride fumes, sulfur oxides (SOx), including sulfur oxide and sulfur dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
F (Not subject to toxicity classification)
Exposure effects
Effects may be delayed.
   Ingestion
May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. The toxicological properties of this substance have not been fully investigated. Can produce delayed pulmonary edema.
   Skin
May cause severe irritation and possible burns.
   Eyes
May cause eye irritation and possible burns. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
HS Code
2921 49 80