Acetamide

  • Acetic acid amide
  • Ethanamide
  • Acetimidic acid
  • Methanecarboxamide
Formula
CH3CONH2
Structure
Description
Colorless crystals with a mousy odor (NTP, 1999).
Uses
Solvent, solubilizer, plasticizer, stabilizer, manufacture methylamine, denaturing alc, in organic syntheses.

Registry Numbers and Inventories.
CAS
60-35-5
EC (EINECS/ELINCS)
200-473-5
EC Index Number
616-022-00-4
EC Class
Carcinogenic Category 3
RTECS
AB4025000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector
Merck
13,44
Beilstein/Gmelin
1071207
Beilstein Reference
4-02-00-00399
Swiss Giftliste 1
G-1025
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C2H5NO
Formula mass
59.07
Melting point, °C
78 - 81
Boiling point, °C
221.1
Vapor pressure, mmHg
0.04 (25 C)
Vapor density (air=1)
aprox. 2
Density
1.14 g/cm3
Solubility in water
2000 g/L
Viscosity
1.32 cp (105 C)
Refractive index
1.4274 (20 C)
Partition coefficient, pKow
-1.26
Heat of fusion
15.6 kJ/mol
Heat of vaporization
81.30 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Minimize dust generation and accumulation. Ground and bond containers when transferring material. Avoid contact with skin and eyes. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Use with adequate ventilation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation. Clean up residual material by washing area with a 2-5% solution of soda ash.
Disposal code
9
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizers, metals, halogenated materials.
Decomposition
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
126
Upper exp. limit, %
20.5
Lower exp. limit, %
3.6
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Dusts may be combustible when exposed to heat, flame, or oxidizing agents. Dust can be an explosion hazard when exposed to heat or flame. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water or foam may cause frothing. Use water spray to cool fire-exposed containers.
Fire potential
This material is probably combustible.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA PEL: 15 mg/m3 total dust, 5 mg/m3 respirable fraction for nuisance dusts.
Carcinogin
I-2B, CP65
Poison_Class
5
Exposure effects
Possible cancer hazard based on tests with laboratory animals. May cause cancer according to animal studies. Chronic exposure may cause liver damage.
   Ingestion
Ingestion of large amounts may cause gastrointestinal irritation. May cause liver damage.
   Inhalation
May cause respiratory tract irritation. May cause liver damage.
   Skin
Causes mild skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. DO NOT use mouth-to-mouth respiration.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
USCG CHRIS Code
ATD
 
HS Code
2924 19 00