Acetazolamide

  • Acetazolamid
  • 5-Acetamide-1,3,4-thiadiazole-2-sulfonamide
  • 2-Acetamido-5-sulfonamido-1,3,4-thiadiazole
  • Acetamidothiadiazolesulfonamide
  • Acetamox
Formula
C4H6N4O3S2
Structure
Description
White to yellowish-white fine crystalline powder. No odor or taste.
Uses
pharmaceutical

Registry Numbers and Inventories.
CAS
59-66-5
EC (EINECS/ELINCS)
200-440-5
RTECS
AC8225000
RTECS class
Drug; Reproductive Effector; Human Data
UN (DOT)
2811
Merck
13,54
Beilstein/Gmelin
212994
Beilstein Reference
4-27-00-08219
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C4H6N4O3S2
Formula mass
222.25
Melting point, °C
258-259
Density
1.771 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
6.80 (pKb)

Hazards and Protection.
Storage
Store between 15 and 30C (59 and 86F), in a well-closed container, unless otherwise specified by manufacturer.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Sensitive to light.
Incompatibilities
Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents Flammable gases are formed by mixing materials in this group with alkali metals Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Fire.
Fire fighting
Fires involving this chemical can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
in overdose lethargy and coma have been reported in children ingesting thiazide diuretics. Altered mental status, headache, hypertonia, muscle weakness, and seizures may develop secondary to diuretic-induced electrolyte abnormalities. Ototoxicity occurs rarely and is usually reversible.
   Inhalation
Noncardiogenic pulmonary edema after hydrochlorothiazide ingestion has been reported and is believed to be an idiosyncratic reaction.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
2811
Response guide