Acetophenone

  • Acetylbenzene
  • 1-Phenylethanone
  • Phenyl methyl ketone
  • Methyl phenyl ketone
Formula
CH3COC6H5
Structure
Description
Colorless liquid, sweet, almond odor.
Uses
In perfumery to impart an orange-blossom-like odor, catalyst for polymerization of olefins, in organic synthesis, esp as photosensitizer.

Registry Numbers and Inventories.
CAS
98-86-2
EC (EINECS/ELINCS)
202-708-7
EC Index Number
606-042-00-1
EC Class
Harmful; Irritant
R 22 36
RTECS
AM5250000
RTECS class
Mutagen; Primary Irritant
UN (DOT)
1993
Merck
13,74
Beilstein/Gmelin
605842
Beilstein Reference
4-07-00-00619
RCRA
U004
EPA OPP
129033
Swiss Giftliste 1
G-1034
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C8H8O
Formula mass
120.15
Melting point, °C
20
Boiling point, °C
201.7
Vapor pressure, mmHg
0.3 (25 C)
Saturation Concentration
Approximately 1300 ppm (0.13%) at 20 C (calculated)
Evaporization number
0.06 (Butyl acetate = 1)
Odor Threshold Odor threshold 0.01-0.025 mg/m3
Critical temperature
428
Critical pressure
3.8
Density
1.027 g/cm3 (20 C)
Solubility in water
5.5 g/L
Viscosity
2.28 cp @ 11.9C
Surface tension
39.8 g/s2 @ 20 C (in contact with vapor)
Refractive index
1.5339 (20 C)
Dielectric constant
8.6 (20 C)
Partition coefficient, pKow
1.58
Heat of vaporization
49.0 kJ/mol

Hazards and Protection.
Storage
Keep away from heat and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong bases, strong reducing agents, aldehydes, nitric acid + hydrogen peroxide, perchloric acid.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
82
Autoignition, °C
570
Upper exp. limit, %
5.2
Lower exp. limit, %
1.4
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Containers may explode when heated. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Slight when exposed to head or flame.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: 10 ppm; 49 mg/m3 (ACGIH 1993-1994).
Poison_Class
4
Exposure effects
Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. Laboratory experiments have resulted in mutagenic effects. Narcotic in high concentrations.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.
   Inhalation
Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Material has a low vapor pressure, so exposure to vapor is not likely.
   Skin
Causes skin irritation.
   Eyes
May cause transient corneal injury. Causes severe eye irritation and possible injury.

First aid
 
   Ingestion
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1993
Response guide
Hazard class
3
Packing Group
I; II; III
 
USCG CHRIS Code
ACP
 
HS Code
2914 39 00
 
Std. Transport #
4915745
 
IMO Pollution Category
D@