Acetylsalicylic acid

  • Aspirin
  • 2-(Acetyloxy)benzoic acid
  • o-Acetylsalicylic acid
Formula
C9H8O4
Structure
Description
Odorless white crystals or crystalline powder with a slightly bitter taste.
Uses
Medication.

Registry Numbers and Inventories.
CAS
50-78-2
EC (EINECS/ELINCS)
200-064-1
R 22 36/37
S 26 36/37/39
RTECS
VO0700000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
2811
Merck
13,856
Beilstein/Gmelin
779271
Beilstein Reference
4-10-00-00138
EPA OPP
129061
Swiss Giftliste 1
G-3736
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H8O4
Formula mass
180.16
Boiling point, °C
140
Vapor pressure, mmHg
3E-5
Density
1.39 g/cm3
Solubility in water
3.3 g/L
Refractive index
1.5623 (20 C)
pKa/pKb
3.49 (pKa)
Partition coefficient, pKow
1.19
Heat of fusion
19.3 kJ/mol
Heat of vaporization
106.40 kJ/mol
Heat of combustion
-3927 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong alkali, hydrolyzes in moist air, decomposes in hot water.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
250
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.
Fire potential
This chemical is combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OEL-UNITED KINGDOM:TWA 5 mg/m3
Poison_Class
3
Exposure effects
Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhibits platelet aggregation affecting bleeding
   Inhalation
May cause respiratory tract irritation. Can produce anaphylactic shock with even small doses.
   Skin
May cause skin irritation. Low hazard for usual industrial handling. Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes.
   Eyes
May cause eye irritation and possible burns.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
4. Organic acids