Acitretin

  • Neotigason
  • Soriatane
  • 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
Formula
C21H26O3
Structure
Description
White powder.
Uses
Used to treat severe psoriasis. Only used when other treatments prove ineffective.

Registry Numbers and Inventories.
CAS
55079-83-9
EC (EINECS/ELINCS)
259-474-4
61 36/38 50/53
53 37/39 45 60 61
RTECS
RA8460000
RTECS class
Drug; Reproductive Effector; Human Data
UN (DOT)
3077
Merck
12,114
Beilstein/Gmelin
2158933
Beilstein Reference
6-10

Properties.
Formula
C21H26O3
Formula mass
326.44
Melting point, °C
219 - 220
Boiling point, °C
521
Vapor pressure, mmHg
1E-11 (25 C)
Solubility in water
Insoluble
pKa/pKb
4.79 (pKa)
Heat of vaporization
83.6 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Flash Point,°C
180
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
May burn but does not ignite readily.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Toxic. Dangerous for the environment. May cause harm to the unborn child. Irritating to eyes and skin. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
   Ingestion
May be harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
Causes skin irritation. May be harmful if absorbed through the skin.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
3077
Response guide
Hazard class
9
Packing Group
III