Acrylamide

  • 2-Propenamide
  • Acrylic acid amide
  • AAM
Formula
CH2CHCONH2
Structure
Description
White, odorless, crystalline solid.
Uses
Used for sewage and waste treatment, to make dyes, adhesives.

Registry Numbers and Inventories.
CAS
79-06-1
EC (EINECS/ELINCS)
201-173-7
EC Index Number
616-003-00-0
EC Class
Carcinogenic Category 2; Mutagenic Category 2; Toxic for reproduction Category 3; Toxic; Harmful; Irritant; Sensitising
R 45 46 20/21 36/38 43 48/23/24/25 62
RTECS
AS3325000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
2074
Merck
13,131
Beilstein/Gmelin
605349
Beilstein Reference
4-02-00-01471
RCRA
U007
EPA OPP
600008
Swiss Giftliste 1
G-1048
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C3H5NO
Formula mass
71.08
Melting point, °C
84
Boiling point, °C
232
Vapor pressure, mmHg
0.007 (25 C)
Vapor density (air=1)
2.45
Saturation Concentration
Approximately 9 ppm at 25 C (calculated)
Critical temperature
438
Critical pressure
54.7
Density
1.122 g/cm3 (20 C)
Solubility in water
2150 g/L
Partition coefficient, pKow
-0.67
Heat of vaporization
46.8 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Do not store in direct sunlight. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from acids. Do not store near alkaline substances. Keep away from polymerization catalysts.
D1B D2A D2B
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use with adequate ventilation.
Protection
Skin: Rubber or neoprene gloves and additional protection including impervious boots, apron, or coveralls, as needed in areas of unusual exposure. Eyes: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Stability
May polymerize explosively. Thermally unstable. Polymerization may be caused by exposure to heat, U.V. light, oxidizers, or peroxides. May be stabilized with hydroquinone, t-butylpyrocatechol, N-phenyl-2-naphthylamine, or other antioxidants.
Incompatibilities
Acids, oxidizing agents, and bases. Spontaneously reacts with hydroxyl-, amino-, and sulfhydryl- containing compounds.
Decomposition
Carbon monoxide, oxides of nitrogen, carbon dioxide, hydrogen gas, ammonia.

Fire.
Flash Point,°C
122
Autoignition, °C
240
Upper exp. limit, %
20.6
Lower exp. limit, %
2.7
Fire fighting
Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.For small fires, use dry chemical, carbon dioxide, water spray or foam. For large fires use water spray, fog or foam. Move container from fire area if you can do so without risk.
Fire potential
May polymerize on melting.
Hazards
Pure acrylamide will decompose at 347-572F giving ammonia, hydrogen and carbon monoxide. Avoid strong oxidizers. Avoid heat, ultraviolet light. Hazardous polymerization may occur. It readily polymerizes when heated to the melting point or when exposed to ultraviolet light. It is known to polymerize with violence when heated.
Combustion products
Toxic oxides of nitrogen are produced during combustion.
Health
2
 
Flammability
2
 
 
Reactivity
2
 

Health.
Exposure limit(s)
OSHA PEL: TWA 0.3 mg/m3 skin NIOSH REL: Ca TWA 0.03 mg/m3 skin See Appendix A NIOSH IDLH: Potential occupational carcinogen 60 mg/m3
Carcinogin
G-A3, I-2A, N-2, CP65
Poison_Class
2
Exposure effects
rolonged or repeated exposure through any route may cause muscular weakness, incoordination, skin rashes, excessive sweating of hands and feet, cold hands, peeling of the skin, numbness, abnormal skin or muscle sensations, fatigue, and cause central and peripheral nervous system damage. Suspect cancer hazard. May cause cancer. May affect the reproductive system and act as a teratogen.
   Ingestion
Harmful if swallowed. Can cause nervous system damage. May cause central, peripheral, and autonomic nervous system effects. Central nervous system effects, which appear to predominate in acute cases, are characterized by abnormal fatigue, memory difficulties, and dizziness. Peripheral neuropathy symptoms, which are more common with repeated low-dose exposure or following a latency period of up to several weeks after acute exposure can include: muscular weakness, paresthesia, numbness in hands, feet, lower legs, and lower arms, unsteadiness, and difficulties in walking and standing. Autonomic nervous system involvement is indicated by excessive sweating, peripheral vasodilation and difficulties in micturation and defecation.
   Inhalation
May cause drowsiness, tingling sensations, fatigue, weakness, stumbling, slurred speech, and shaking. May cause central and peripheral nervous system damage. Severe intoxications may cause permanent nerve damage. Causes irritation to the respiratory tract. May affect reproductive system and act as a teratogen.
   Skin
May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, causes symptoms similar to those of ingestion.
   Eyes
May cause eye irritation and possible burns.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2074
Response guide
Hazard class
6.1
Packing Group
III
 
USCG CHRIS Code
AAM
 
HS Code
2924 19 00
 
Std. Transport #
4912087
 
IMO Chemical Code
17
IMO Pollution Category
D
IMO Hazard code
S