Actinomycin C

  • Cactinomycin
  • Sanamycin
Formula
C62H86N12O16
Uses
Inhibitor of DNA-dependent RNA synthesis.

Registry Numbers and Inventories.
CAS
8052-16-2
EC (EINECS/ELINCS)
232-485-1
46 61 26/27/28
53 36/37/39 45
RTECS
AU1400000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Natural Product
UN (DOT)
2811
Merck
13,1606
Beilstein/Gmelin
7286288
Beilstein Reference
6-27
New Zealand
Listed

Properties.
Formula
C62H86N12O16
Formula mass
1255.44
Melting point, °C
252

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing. Faceshield (8-inch minimum).
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Strong oxidizing agents, Strong acids, Strong bases.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
May cause cancer. May cause heritable genetic damage. May cause harm to the unborn child. Very toxic by inhalation, in contact with skin and if swallowed. Possible sensitizer. Causes burns. Target org
   Ingestion
See Inhalation.
   Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
   Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
   Eyes
Immediately flush with running water for at least 20 minutes.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
II