Aflatoxin B2

  • Dihydroaflatoxin b1
  • Dihydroaflatoxine b1
  • 2,3,6a-alpha,8,9,9a-alpha-Hexahydro-4-methoxycyclopenta(C)furo(3',2':4,5)furo(2,3-H)(1)benzopyran-1,11-dione
Formula
C17H14O6
Structure
Description
Off-white powder.
Uses
A potent hepatotoxic and hepatocarcinogenic mycotoxin.

Registry Numbers and Inventories.
CAS
7220-81-7
EC (EINECS/ELINCS)
230-618-8
RTECS
GY1722000
RTECS class
Tumorigen; Mutagen; Natural Product
UN (DOT)
2811
Beilstein/Gmelin
1355115
Beilstein Reference
5-19-10-00552

Properties.
Formula
C17H14O6
Formula mass
314.31
Melting point, °C
286
Decomposition point, °C
286-289

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked/refrigerator. Store protected from moisture. Store protected from light.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Store protected from light. Do not allow contact with water. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Do not get water inside containers.
Stability
Stable under normal temperatures and pressures. Air sensitive Light sensitive.
Incompatibilities
Strong oxidizing agents, strong acids, strong bases, moisture.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Extinguishing media: Use agent most appropriate to extinguish fire. Do NOT get water inside containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
May cause cancer in humans. Laboratory experiments have resulted in mutagenic effects.
   Ingestion
May be fatal if swallowed. May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May be fatal if inhaled. May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation. May be fatal if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Get medical aid immediately. If conscious drink water, then induce vomiting. If unconscious, immediately take victim to a physician and do NOT attempt to induce vomiting.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III