Alfacalcidol

  • 1-Hydroxycholecalciferol
  • 1a-Hydroxyvitamin D3
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3-diol, (1a,3b,5Z,7E)
Formula
C27H44O2
Structure
Description
Fine white crystals
Uses
A form of vitamin D. It is converted rapidly in the liver to the active metabolite, 1,25-dihydroxycholecalciferol (calcitriol).

Registry Numbers and Inventories.
CAS
41294-56-8
EC (EINECS/ELINCS)
255-297-1
26/27/28
28 36/37 45
RTECS
VS2851000
RTECS class
Drug; Reproductive Effector
UN (DOT)
2811
Merck
12,4864
Beilstein/Gmelin
1916848
Beilstein Reference
5-06
EPA OPP
126401
Canada DSL/NDSL
DSL
New Zealand
Listed

Properties.
Formula
C27H44O2
Formula mass
400.65
Melting point, °C
132 - 133
Vapor pressure, mmHg
2E-13 (25 C)
Solubility in water
Insoluble
pKa/pKb
13.82 (pKa)
Heat of vaporization
92.83 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at -20 C
Protection
Compatible chemical-resistant gloves.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Very toxic by inhalation, in contact with skin and if swallowed.
   Ingestion
May be fatal if swallowed.
   Inhalation
May be fatal if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be fatal if absorbed through skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I