Allopurinol

  • Adenock
  • Al-100
  • Allopur
  • Allopurinol(I)
  • Allozym
  • Allural
Formula
C5H4N4O
Structure
Description
Odorless tasteless white microcrystalline powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
315-30-0
EC (EINECS/ELINCS)
206-250-9
RTECS
UR0785000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,287
Beilstein/Gmelin
133199
Beilstein Reference
4-26-00-02076
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C5H4N4O
Formula mass
136.11
Melting point, °C
>350
Vapor density (air=1)
4.69
Density
1.635 g/cm3
Solubility in water
Slightly soluble
pKa/pKb
9.4 (pKa)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Repeated exposure may cause sensitization dermatitis. Effects may be delayed.
   Ingestion
May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause blood abnormalities. Ingestion of large amounts may cause liver and/or kidney damage.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause irritation and dermatitis.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.