Amantadine

  • 1-Aminoadamantane
Formula
C10H17N
Structure
Description
Off-white to pale-yellow powder.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
768-94-5
EC (EINECS/ELINCS)
212-201-2
RTECS
YD1925000
RTECS class
Drug; Mutagen
Merck
12,389
Beilstein/Gmelin
2204333
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed

Properties.
Formula
C10H17N
Formula mass
151.25
Melting point, °C
82
Boiling point, °C
214
Critical temperature
434
Critical pressure
34.4
Solubility in water
Insoluble
Partition coefficient, pKow
2.47

Hazards and Protection.
Storage
Store in a cool, dry location. Keep containers tightly sealed.
Handling
Use only in a chemical fume hood. Only handly while using the recommended protective equipment. Remove and launder contaminated clothing and shoes before reuse.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
NIOSH/MSHA approved respirator.
Small spills/leaks
Evacuate area. Wear SCB A, rubber boots and gloves. Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Provide adequate ventilation. Wash site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Oxides of carbon and nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Initially CNS depression is seen, followed by CNS stimulation. Drowsiness, weakness, confusion, jitteriness, hallucinations, nightmares and apprehension have been reported as has aggressive behavior and seizures after a single 800 mg dose.
   Ingestion
Harmful if swallowed. Nausea.
   Inhalation
Irritation, headache.. Reproductive disorders. COngestive heart failure.
   Skin
Irritation.
   Eyes
Irritation.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.