Aminopterin

  • 4-Aminofolic acid
  • 4-Aminopteroylglutamic acid
  • L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
Formula
C19H20N8O5
Structure
Description
Clusters of yellow needles.
Uses
Is a folic acid antagonist.

Registry Numbers and Inventories.
CAS
54-62-6
EC (EINECS/ELINCS)
200-209-9
RTECS
MA1050000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,493
Beilstein/Gmelin
69045
Beilstein Reference
4-26-00-03831
Swiss Giftliste 1
G-3743
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C19H20N8O5
Formula mass
440.42
Melting point, °C
260-265
pKa/pKb
3.52 (pKa)
Partition coefficient, pKow
0.15

Hazards and Protection.
Storage
Cool dry location in a tightly sealed container. Avoid exposure to light.
Handling
Do not breath dust, get in eyes, on skin or on clothing. Avoid prolonged or repeated exposure. Always work in a chemical hood and while using the recommended protective equipment.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
NIOSH/MSHA approved respirator.
Small spills/leaks
Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Oxides of carbon and nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Poison_Class
1*
Exposure effects
Chronic exposure may cause congenitial malformations of the fetus. Studies havs shown mutagenic effects. Causes blood effects.
   Ingestion
See inhalation.
   Inhalation
May be fatal if inhaled, ingested or absorbed through the skin. Causes irritation.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.
USCG CHRIS Code
APA