Amobarbital

  • AMAL
  • Amasust
  • Amital
  • Amobarbitone
  • Amospan
  • Amybal
Formula
C11H18N2O3
Structure
Description
White crystalline solid with no odor and a slightly bitter taste.
Uses
This is a drug of abuse.

Registry Numbers and Inventories.
CAS
57-43-2
EC (EINECS/ELINCS)
200-330-7
RTECS
CQ5075000
RTECS class
Drug
Merck
12,607
Beilstein/Gmelin
211172
Beilstein Reference
5-24-09-00173
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C11H18N2O3
Formula mass
226.28
Melting point, °C
156-158
Solubility in water
0.78 g/L
Refractive index
1.4584
pKa/pKb
7.94 (pKa)
Partition coefficient, pKow
2.07
Heat of fusion
22.8 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Fire.
Fire fighting
Fires involving this compound can be controlled with dry chemical, carbon dioxide or Halon extinguishers.

Health.
Exposure effects
CNS findings range from drowsiness to deep coma. Seizures are not expected, except upon withdrawal from barbiturate dependence.
   Ingestion
Respiratory arrest may occur following severe intoxication. Aspiration pneumonia has been reported, in barbiturate ingestions, following vomiting of gastric contents.
   Inhalation
Respiratory arrest may occur following severe intoxication. Aspiration pneumonia has been reported, in barbiturate ingestions, following vomiting of gastric contents.
   Skin
Erythematous or hemorrhagic blisters (barb - burns) may occasionally occur on the hands, buttocks, in between the knees, and at any pressure point.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.