Amoxapine

  • Amoxan
  • Moxadil
  • Asendin
  • 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine
Formula
C17H16ClN3O
Structure
Description
white solid
Uses
Tricyclic antidepressant.

Registry Numbers and Inventories.
CAS
14028-44-5
EC (EINECS/ELINCS)
237-867-1
RTECS
HQ4025500
RTECS class
Drug; Human Data
Merck
12,616
Beilstein/Gmelin
832057
Beilstein Reference
6-27
New Zealand
Listed

Properties.
Formula
C17H16ClN3O
Formula mass
313.79
Melting point, °C
175 - 176
Boiling point, °C
470
Vapor pressure, mmHg
5E-9 (25 C)
Solubility in water
Insoluble
pKa/pKb
5.97 (pKb)
Heat of vaporization
73.2 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Flash Point,°C
238
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful if swallowed. Calif. Prop. 65 reproductive hazard. Target organ(s): Heart. Central nervous system.
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.