Amphetamine

  • Actedron
  • Adipan
  • Allodene
  • beta-Aminopropylbenzene
  • Dl-Amphetamine
  • Anorexide
Formula
C9H13N
Structure
Description
Colored liquid with an amine odor.
Uses
Amphetamines have been used in sports as energy chemicals. Athletes trying to achieve the competitive edge may use amphetamines to increase their sports performances, especially in track and field, football, and swimming. The use of amphetamines has been banned by the international olympic committee (ioc), the national collegiate athletic association (ncaa) and most professioinal sport organizations. Amphetamines.

Registry Numbers and Inventories.
CAS
300-62-9
EC (EINECS/ELINCS)
206-096-2
RTECS
SH9450000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,623
Beilstein/Gmelin
507867
Beilstein Reference
4-12-00-02587
Canada DSL/NDSL
DSL
US TSCA
Listed

Properties.
Formula
C9H13N
Formula mass
135.21
Boiling point, °C
44 (0.3 torr)
Vapor density (air=1)
4.65
Density
0.937 g/cm3 (18 C)
Solubility in water
Insoluble
Refractive index
1.5175 (20 C)
pKa/pKb
3.87 (pKb)
Partition coefficient, pKow
1.76

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
(Non-Specific -- Drugs, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Shut off ignition sources; no flares, smoking or flames in hazard area. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch spilled material. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal.
Stability
No data.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Fire.
Flash Point,°C
<100 (open cup)
Fire fighting
Extinguish with carbon dioxide or dry chemical.
Fire potential
Flammable, moderate fire risk. Combustible when exposed to heat, flame, or oxidizers.
Hazards
Dangerous when exposed to heat or flames. Upon decomposition, nitrogen oxides are emitted. Can react with oxidizing materials.
Health
3
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Severe elevated body temperature may develop. Elevated blood pressure and rapid heart rate are common. Agitation, confusion, paranoia, delirium, hallucinations, restlessness, hyperactivity, talkativeness, irritability, insomnia, and headache are common. Chorea, dystonia, fasciculations, muscle rigidity, tics, and tremors may develop. Seizures and coma may occur with severe intoxication. Other neurological effects have included stroke and cerebral vasculitis. Serotonin syndrome has occurred.
   Ingestion
Vomiting, diarrhea, cramps, anorexia and gastrointestinal hemorrhage may occur.
   Inhalation
Tachypnea is common. Pulmonary hypertension has been associated with chronic use or abuse which may result from contaminants. Pulmonary edema and ards are unusual complications of severe exposure.
   Skin
The skin is usually flushed and diaphoretic.

First aid
 
   Ingestion
Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.