Aniline

  • Aniline oil
  • Aminobenzene
  • Phenylamine
  • Benzenamine
  • Benzeneamine
Formula
C6H5NH2
Structure
Description
Colorless, oily liquid when pure with a characteristic musty, fishy, amine-like aromatic odor, darkens on exposure to light and air, forming an impure product.
Uses
Manufacture resins, varnishes, perfumes, shoe blacks, as solvent.

Registry Numbers and Inventories.
CAS
62-53-3
EC (EINECS/ELINCS)
200-539-3
EC Index Number
612-008-00-7
EC Class
Carcinogenic Category 3; Toxic; Harmful; Dangerous for the Environment
R 20/21/22 40 48/23/24/25 50
S 28 36/37 45 61
RTECS
BW6650000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
1547
Merck
13,661
Beilstein/Gmelin
605631
Beilstein Reference
4-12-00-00223
RCRA
U012
EPA OPP
251400
Swiss Giftliste 1
G-1131
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H7N
Formula mass
93.13
Melting point, °C
-6.2
Boiling point, °C
184
Vapor pressure, mmHg
0.6 (25 C)
Vapor density (air=1)
3.22
Saturation Concentration
400 ppm (0.04%) at 20 C; 900 ppm (0.09%) at 25 C (calculated)
Evaporization number
Less than 1 (butyl acetate = 1)
Odor Threshold Odor threshold 0.5 ppm
Critical temperature
426
Critical pressure
52.4
Density
1.019 g/cm3 (20 C)
Solubility in water
34 g/L
Viscosity
4.35 cp @ 20C
Surface tension
42.58 g/s2 (20 C)
Refractive index
1.5863 (20 C)
Dipole moment
1.55 D (20 C)
Dielectric constant
6.89 (20 C)
pKa/pKb
9.40 (pKb)
Partition coefficient, pKow
0.90
Heat of fusion
10.6 kJ/mol
Heat of vaporization
52.8 kJ/mol
Heat of combustion
-3394 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Keep away from acids. Material darkens in color on storage. Store protected from moisture. Store protected from light.
B3 D1A D2B
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Store protected from light. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures. Volatile in steam. Sensitive to Light. May discolor on exposure to air and light.
Incompatibilities
Strong oxidizing agents, strong acids, bases, aluminum, fluorine, formaldehyde, iron, nitric acid, silver perchlorate, sodium peroxide, sulfuric acid, zinc, hydrogen peroxides, ozone, acid anhydrides, chlorosulfonic acid, oleum, perchromates, nitromethane, dibenzoyl peroxide, benzenediazonium-2-carboxylate, boron trichloride, tetranitromethane, trichloronitromethane, diisopropyl peroxydicarbonate, hexachloromelamine, peroxomonosulfuric acid, albumin, iron salts, perchloric acid, nitrobenzene, alkalis, moisture, potassium peroxide, glycerine, fuming nitric acid, N-chloro compounds, N-bromoimides (e.g. n-bromosuccinimide), peroxydisulfuric acid, nitrosyl fluoride, toluene diisocyanate.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
76
Autoignition, °C
540
Upper exp. limit, %
11
Lower exp. limit, %
1.2
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Containers may explode when heated. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Use extinguishing media most appropriate for the surrounding fire.
Fire potential
Moderately flammable. Combustion requires preheating. Volatile with steam.
Hazards
Combustion can produce toxic fumes including nitrogen oxides and carbon monoxide. Aniline vapor forms explosive mixtures with air. It is incompatible with strong oxidizers and strong acids and a number of other materials. Avoid heating. Hazardous polymerization may occur. Polymerizes to a resinous mass.
Combustion products
Toxic gases and vapors (such as oxides of nitrogen and carbon monoxide) may be released in a fire involving aniline.
Health
3
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: 2 ppm; 7.6 mg/m3 (as TWA) (skin) (ACGIH 1992-1993). OSHA PEL: TWA 5 ppm (19 mg/m3) skin NIOSH REL: Ca See Appendix A NIOSH IDLH: Potential occupational carcinogen 100 ppm
Carcinogin
G-A3, CP65
Poison_Class
1*
Exposure effects
May cause liver and kidney damage. May cause fetal effects. Repeated exposure may cause sensitization dermatitis. Chronic exposure may cause hemolysis of the red blood cells followed by stimulation of the bone marrow. Laboratory experiments have resulted in mutagenic effects. May cause cyanosis - a blue-gray coloring of the skin and lips caused by a lack of oxygen. Animal studies have reported the development of tumors.
   Ingestion
Harmful if swallowed. Aniline acts through an intermediate to change hemoglobin to methemoglobin. In one subject, 65 mg of aniline increased the methemoglobin level by 16% within 2 hours. Intense methemoglobinemia may lead to asphyxia severe enough to injure the cells of the central nervous system. Pathologic findings in acute fatalities from aniline include chocolate color of the blood; injury to the kidney, liver and spleen; and hemolysis. Alcohol can intensify the ability of aniline to induce methemoglobinemia.
   Inhalation
Harmful if inhaled. Causes respiratory tract irritation. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown blood. Inhalation of aniline causes anoxia due to the formation of methemoglobin.
   Skin
Causes skin irritation. Harmful if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Vapors are readily absorbed through the skin.
   Eyes
Causes severe eye irritation. May cause lacrimation (tearing), blurred vision, and photophobia. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
1547
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
ANL
 
9 Aromatic amines
HS Code
2921 41 00
 
Std. Transport #
4921410 4921492
 
IMO Chemical Code
17
IMO Pollution Category
C
IMO Hazard code
S/P