Anisidine (mixed isomers)

  • Anisidine (o-, p- isomers)
  • Methoxyaniline
Formula
C7H9NO
Structure
Description
Red to yellow oily liquid. Characteristic odor. Turns brown on exposure to air.
Uses
Intermediate in the manufacturing of dyes, pharmaceuticals, and fragrances.

Registry Numbers and Inventories.
CAS
29191-52-4
EC (EINECS/ELINCS)
249-496-2
RTECS
BZ5410000
UN (DOT)
2431
Beilstein/Gmelin
NA
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C7H9NO
Formula mass
123.8
Melting point, °C
5
Boiling point, °C
213
Vapor pressure, mmHg
0.1
Vapor density (air=1)
4.25
Critical temperature
455
Critical pressure
42.0
Density
1.1 g/cm3 (20 C)
Solubility in water
1.5 g/100 ml
Partition coefficient, pKow
1.1

Hazards and Protection.
Storage
Keep well closed and protected from light Storage site should be close to lab so that only small quantities required for experimentation need to be carried. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Protective gloves and clothing. Face shield.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Stability
Heat may contribute to instability.
Incompatibilities
Sensitive to heat Sensitive to exposure to light Incompatible with strong oxidizers Incompatible with acids, acid chlorides, acid anhydrides and chloroformates.
Decomposition
When heated to decomposition evolves toxic fumes of nitrogen oxides. Anisidine o-, p-isomers toxic gases and vapors (such as carbon monoxide) may be released when anisidine decomposes.

Fire.
Flash Point,°C
118
Autoignition, °C
415
Fire fighting
Small Fires: Dry chemical, carbon dioxide or water spray. Large Fires: Dry chemical, carbon dioxide, alcohol-resistant foam or water spray.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA PEL: TWA 0.5 mg/m3 skin NIOSH REL: Ca 0.5 mg/m3 skin See Appendix A NIOSH IDLH: Potential occupational carcinogen 50 mg/m3
Carcinogin
G-A3, I-2B
Exposure effects
CNS effects include headache, dizziness, altered mental status, confusion (lethargy progressing coma), seizures, syncope; occur secondary to CNS hypoxia, usually with levels > 20%.
   Ingestion
Blue lips, fingernails, skin. See inhalation.
   Inhalation
Acute effects - Blue lips, fingernails, skin. Convulsions, dizziness, headache, nausea, unconsciousness. May cause effects on the blode, resulting in formation of methaemoglobin. Effects may be delayed.<BR>Chronic effects - Possibly carcinogenic to humans.
   Skin
Blue lips, fingernails, skin. See inhalation. May be absorbed through skin.
   Eyes
See Inhalation.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
   Skin
Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
   Eyes
Immediately flush with running water for at least 20 minutes.

Transport.
UN number
2431
Response guide
Hazard class
6.1
Packing Group
III