Anisidine (mixed isomers)
- Anisidine (o-, p- isomers)
Red to yellow oily liquid. Characteristic odor. Turns brown on exposure to air.
Intermediate in the manufacturing of dyes, pharmaceuticals, and fragrances.
Registry Numbers and Inventories.
Japan ENCS (MITI)
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
Vapor density (air=1)
1.1 g/cm3 (20 C)
Solubility in water
1.5 g/100 ml
Partition coefficient, pKow
Hazards and Protection.
Keep well closed and protected from light Storage site should be close to lab so that only small quantities required for experimentation need to be carried. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protective gloves and clothing. Face shield.
Wear positive pressure self-contained breathing apparatus (SCBA).
ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Heat may contribute to instability.
Sensitive to heat Sensitive to exposure to light Incompatible with strong oxidizers Incompatible with acids, acid chlorides, acid anhydrides and chloroformates.
When heated to decomposition evolves toxic fumes of nitrogen oxides. Anisidine o-, p-isomers toxic gases and vapors (such as carbon monoxide) may be released when anisidine decomposes.
Small Fires: Dry chemical, carbon dioxide or water spray. Large Fires: Dry chemical, carbon dioxide, alcohol-resistant foam or water spray.
Combustible material: may burn but does not ignite readily.
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Fire may produce irritating, corrosive and/or toxic gases.
OSHA PEL: TWA 0.5 mg/m3 skin NIOSH REL: Ca 0.5 mg/m3 skin See Appendix A NIOSH IDLH: Potential occupational carcinogen 50 mg/m3
CNS effects include headache, dizziness, altered mental status, confusion (lethargy progressing coma), seizures, syncope; occur secondary to CNS hypoxia, usually with levels > 20%.
Blue lips, fingernails, skin. See inhalation.
Acute effects - Blue lips, fingernails, skin. Convulsions, dizziness, headache, nausea, unconsciousness. May cause effects on the blode, resulting in formation of methaemoglobin. Effects may be delayed.<BR>Chronic effects - Possibly carcinogenic to humans.
Blue lips, fingernails, skin. See inhalation. May be absorbed through skin.
Seek medical assistance.
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
Immediately flush with running water for at least 20 minutes.