Antizol

  • Fomepizole
  • 4-Methylpyrazole
  • 4-Methyl-1H-pyrazole
  • 4-MP
Formula
C4H6N2
Structure
Description
Yellow liquid.
Uses
antidot for ethylene glycol poisoning treatment

Registry Numbers and Inventories.
CAS
7554-65-6
EC (EINECS/ELINCS)
231-445-0
R 22 36/37/38
S 26 36/37/39
RTECS
UQ7350000
RTECS class
Other
Merck
13,4242
Beilstein/Gmelin
105204
Beilstein Reference
5-23-05-00031

Properties.
Formula
C4H6N2
Formula mass
82.10
Melting point, °C
16 - 19
Boiling point, °C
244
Vapor pressure, mmHg
0.05 (25 C)
Vapor density (air=1)
2.83
Density
1.0183 g/cm3 (17 C)
Solubility in water
Soluble
Refractive index
1.4895 (16.7 C)
pKa/pKb
10.79 (pKb)
Partition coefficient, pKow
0.78
Heat of vaporization
46.1 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - strong acids - acid chlorides.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
96
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
   Inhalation
Causes respiratory tract irritation.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.