Apocynin

  • Acetoguaiacone
  • Acetovanillone
  • 4-Acetylguaiacol
  • 4-Acetyl-2-methoxyphenol
  • 4'-Hydroxy-3'-methoxyacetophenone
  • 1-(4-Hydroxy-3-methoxyphenyl)ethanone
Formula
C9H10O3
Structure
Description
Light yellow to yellow solid. Faint vanilla odor.
Uses
A plant-derived, cartilage-saving drug, might be useful in the treatment of rheumatoid arthritis.

Registry Numbers and Inventories.
CAS
498-02-2
EC (EINECS/ELINCS)
207-854-5
R 36/37/38
RTECS
AM8800000
RTECS class
Drug; Mutagen
Merck
13,746
Beilstein/Gmelin
637373
Beilstein Reference
4-08-00-01814
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H10O3
Formula mass
166.18
Melting point, °C
115
Boiling point, °C
295
Vapor pressure, mmHg
0.0008 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
8.17 (pKa)
Partition coefficient, pKow
1.38
Heat of vaporization
55.9 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidants.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
126
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Health.
Exposure effects
   Ingestion
The toxicological properties of this substance have not been fully investigated.
   Inhalation
The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
HS Code
2914 50 00