Aprobarbital

  • Allional
  • Allonal
  • Allylisopropylbarbituric acid
  • 5-Allyl-5-Isopropylbarbituric acid
  • Allylisopropylmalonylurea
  • Allylpropymal
Formula
C10H14N2O3
Structure
Description
Crystals.
Uses
Medication.

Registry Numbers and Inventories.
CAS
77-02-1
EC (EINECS/ELINCS)
200-997-4
RTECS
CP8925000
RTECS class
Drug
Merck
12,794
Beilstein/Gmelin
180858
Beilstein Reference
5-24-09-00224
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C10H14N2O3
Formula mass
210.23
Melting point, °C
140-142
Solubility in water
Slightly soluble
Refractive index
1.4842
pKa/pKb
7.83 (pKa)
Partition coefficient, pKow
1.27
Heat of fusion
21.4 kJ/mol

Hazards and Protection.
Storage
Oral solution should be stored in tight, light-resistant containers at a temperature less than 40C, preferably between 15 to 30C; freezing should be avoided. Expiration date is 4 years following the date of manufacture.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Stable in air.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
CNS findings range from drowsiness to deep coma. Seizures are not expected, except upon withdrawal from barbiturate dependence.
   Ingestion
Respiratory arrest may occur following severe intoxication. Aspiration pneumonia has been reported, in barbiturate ingestions, following vomiting of gastric contents.
   Inhalation
Respiratory arrest may occur following severe intoxication. Aspiration pneumonia has been reported, in barbiturate ingestions, following vomiting of gastric contents.
   Skin
Erythematous or hemorrhagic blisters (barb - burns) may occasionally occur on the hands, buttocks, in between the knees, and at any pressure point.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.