Arabinosyladenine

  • Spongoadenosine
  • 6-Amino-9-b-D-arabinofuranosylpurine
  • 9H-Purin-6-amine, 9-b-D-arabinofuranosyl-
  • Adenine arabinoside
  • Vidarabin
  • NSC 404241
Formula
C10H13N5O4.H2O
Structure
Description
White to off-white crystalline powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
5536-17-4
EC (EINECS/ELINCS)
226-893-9
RTECS
AU6200000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
12,10113
Beilstein/Gmelin
624881
Canada DSL/NDSL
NDSL
US TSCA
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C10H13N5O4
Formula mass
285.26
Melting point, °C
257-258
Solubility in water
Soluble
pKa/pKb
10.75 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Health.
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Symptoms of exposure to this compound include nausea, vomiting, diarrhea, rash, weakness, thrombophlebitis, hallucinations, psychoses, ataxia, tremor, and dizziness. It can cause gastrointestinal disturbances, confusion, anemia, leukopenia, thrombocytopenia, elevated liver enzymes and bilirubin, corneal changes, and sensitivity changes. In addition, it causes mild itching and irritation of the eyes, and moderate redness of the conjunctiva with temporary punctate keratitis. Anorexia, weight loss, and abnormal EKG have been reported. It causes headache, encephalopathy, decrease in hemoglobin, white blood count, platelet count, and malaise, pruritus, and hematemesis.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.