Arsenic trioxide

  • Arsenous acid
  • Arsenous oxide
  • Arsenic(III) oxide
  • Arsenous oxide anhydride
  • Diarsenic trioxide
  • Arsenous acid anhydride
Formula
As2O3
Structure
Description
Colorless, cubic or fibrous (arsenolite). Odorless.
Uses
Acaricide, rodenticide.

Registry Numbers and Inventories.
CAS
1327-53-3
EC (EINECS/ELINCS)
215-481-4
EC Index Number
033-003-00-0
EC Class
Carcinogenic Category 1; Very toxic; Corrosive; Dangerous for the Environment
RTECS
CG3325000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
1561
Merck
12,844
Beilstein/Gmelin
35185 (G)
RCRA
P012
EPA OPP
7001
Swiss Giftliste 1
G-1148
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
As2O3
Formula mass
197.84
Melting point, °C
312
Boiling point, °C
465
Vapor pressure, mmHg
0.0002 (25 C)
Odor Threshold Odor threshold Odorless
Density
4.15 g/cm3 (25 C)
Solubility in water
12 g/L
Dipole moment
0.13 D
Heat of fusion
18.4 kJ/mol
Heat of vaporization
125.1 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not store in metal containers.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Do not allow contact with water.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Do not get water inside containers.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Incompatible with chlorine trifluoride, fluorine, hydrogen fluoride, oxygen difluoride, and sodium chlorate. Can generate arsine, which is an extremely poisonous gas, when arsenic compounds contact acid, alkalies, or water in the presence of an active metal (zinc, aluminum, magnesium, manganese, sodium, iron, etc).
Decomposition
Irritating and toxic fumes and gases, oxides of arsenic, arsine.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use extinguishing media appropriate to the surrounding fire. Substance is noncombustible. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. Do NOT get water inside containers.
Fire potential
Nonflammable.
Hazards
Toxic fumes of arsenic trioxide and arsine may be formed in fire situations. Contact with halide acids will form toxic volatile halides. Reduction in acid solutions will form arsine. Arsenic trioxide and excess zinc filings will explode on heating. Avoid sodium chlorate; fluorine; chlorine trifluoride; chromic oxide; aluminum chloride; phosphorus pentoxide; hydrogen fluoride; oxygen difluoride, tannic acid; infusion cinchona and other vegetable astringent infusions and decoctions; iron in solution. It is stable in air but slowly oxidizes in acid media.
Combustion products
Toxic fumes of arsenic trioxide and arsine may be formed in fire situations.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV (as As): 0.01 ppm; A1 mg/m3 (ACGIH 1996).
Carcinogin
O, G-A1, I-1, N-1, CP65
Poison_Class
1*
Exposure effects
May cause liver and kidney damage. Chronic inhalation may cause nasal septum ulceration and perforation. May cause anemia and other blood cell abnormalities. Chronic skin effects include: cracking, thickening, pigmentation, and drying of the skin. Arsenic trioxide can cause cancer in humans. Other long term effects include: anemia, liver and kidney damage, Chronic exposure to arsenical dust may cause breath shortness, nausea, chest pains, and garlic odor.
   Ingestion
May be fatal if swallowed. Causes severe digestive tract burns with abdominal pain, vomiting, and possible death. May cause hemorrhaging of the digestive tract. Ingestion of arsenical compounds may cause burning of the lips, throat constriction, swallowing difficulties, severe abdominal pain, severe nausea, projectile vomiting, and profuse diarrhea. Ingestion of arsenic compounds can produce convulsions, coma, and possibly death within 24 hours.
   Inhalation
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and leading to possible nasal perforation. Long-term exposure to arsenic compounds may produce impairment of peripheral circulation.
   Skin
Causes irritation with burning pain, itching, and redness. May cause dermatitis. Exposure to arsenic compounds may produce hyperpigmentation of the skin and hyperkeratoses of plantar and palmar surfacesas well as both primary irritation and sensitization types.
   Eyes
Contact produces irritation, tearing, and burning pain. May cause conjunctivitis.

First aid
 
   Ingestion
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1561
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
ATO
 
Std. Transport #
4923115