Atenolol

  • Atehexal
  • Atenol
  • 1-p-Carbamoylmethylphenoxy-3-Isopropylamino-2-propanol
  • 2-(p-(2-Hydroxy-3-(Isopropylamino)propoxy)phenylacetamide
  • 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide
  • Ibinolo
Formula
C14H22N2O3
Structure
Description
White, crystalline powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
29122-68-7
EC (EINECS/ELINCS)
249-451-7
RTECS
AC3600000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,892
Beilstein/Gmelin
2739235
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C14H22N2O3
Formula mass
266.34
Melting point, °C
146-148
Solubility in water
26.5 mg/ml @ 37 C
Partition coefficient, pKow
-2.5

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Low heart rate and abnormally low blood pressure are common. Respiratory depression may occur with severe poisoning. fatigue, sleepiness, headache, sedation and confusion may develop with therapeutic use. CNS depression, coma and seizures may develop in overdose.
   Ingestion
Nausea and vomiting may be noted. Mesenteric ischemia has been reported as a sequelae of overdose.
   Inhalation
Increased airway resistance, wheezing, pulmonary edema, cyanosis, respiratory depression may develop. In severe cases respiratory arrest may occur.
   Eyes
Diplopia and eye irritation may develop with therapeutic use. Mydriasis has been reported overdose.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.