Atropine

  • d,l-Hyoscyamine
  • µ-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo-(3.2.1)oct-3-yl ester
Formula
C17H23NO3
Structure
Description
White powder.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
51-55-8
EC (EINECS/ELINCS)
200-104-8
EC Index Number
614-010-00-3
EC Class
Very toxic
RTECS
CK0700000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
1544
Merck
12,907
Beilstein/Gmelin
91256
Beilstein Reference
5-21-01-00235
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C17H23NO3
Formula mass
289.37
Melting point, °C
115
Boiling point, °C
393
Critical temperature
570
Critical pressure
21.1
Solubility in water
2 g/L
Partition coefficient, pKow
1.53

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Store protected from light.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Non-Combustible
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Reproductive effects have been reported in humans. Exposure to large doses may cause central nervous system depression.
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract. Ingestion of large amounts may cause pain, constipation or diarrhea. Human fatalities have been reported from acute poisoning. May cause an abrupt rise in body temperature, convulsions, and coma. Ingestion may cause headache, nausea, and vomiting.
   Inhalation
May cause respiratory tract irritation. May cause cardiovascular disturbances, hearing abnormalities, central nervous system depression, muscle weakness, and possible death due to respiratory failure.
   Skin
May cause skin irritation. May cause skin rash and eruptions.
   Eyes
May cause eye irritation. May cause lacrimation (tearing), blurred vision, and photophobia.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1544
Response guide
Hazard class
6.1
Packing Group
I; II; III