a-Amanitin

  • a-Amanitine
  • Cyclo[L-asparaginyl-4-hydroxy-L-prolyl-(R)-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl], cyclic (4Æ8)-sulfide, (R)-S-oxide
Formula
C39H54N10O14S
Structure
Description
White solid with a mild odor.
Uses
Inhibitor of Nuclear RNA polymerase II.

Registry Numbers and Inventories.
CAS
23109-05-9
EC (EINECS/ELINCS)
245-432-2
RTECS
BD6195000
RTECS class
Mutagen; Natural Product
Beilstein/Gmelin
1071138
Beilstein Reference
5-27
New Zealand
Listed

Properties.
Formula
C39H54N10O14S
Formula mass
918.97
Melting point, °C
254-255
Density
Soluble. g/cm3 (20 C)

Hazards and Protection.
Storage
Sore in a tightly closed container and protect from moisture, light and ignition sources.
Handling
Good laboratory technique should be used when handling. Observed appropriate chemical hygiene. Avoid contact with skin and eyes. Do not place in mouth.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
NIOSH approved respirator.
Small spills/leaks
Wear protective equipment. Sweep up avoiding dust formation. Absorbent material is not necessary. Place all contaminated material into a suitable container.
Stability
Stable under normal handling and storage conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
No data.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Health
4
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
Very toxic. Symptoms are slow in onset, appearing 6-24 hours after ingestion. They include abdominal pain, blood in urine and diarrhea. Death usually results from liver or renal failure.
   Inhalation
Very toxic. See Ingestion.
   Eyes
May cause irritation.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.