Bacitracin

  • Bacitek ointment
  • Ayfivin
  • Baciguent
  • Baci-Jel
  • Baciliquin
Formula
C66H103N17O16S
Structure
Description
White to pale buff powder. Odorless. Hygroscopic.
Uses
Medication: antibacterial.

Registry Numbers and Inventories.
CAS
1405-87-4
EC (EINECS/ELINCS)
215-786-2
RTECS
CP0175000
RTECS class
Drug; Mutagen
Beilstein/Gmelin
NA
EPA OPP
6302
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C66H103N17O16S
Formula mass
1422.71
Melting point, °C
221 to 225
Solubility in water
Freely soluble

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective gloves and clothing to prevent skin exposure.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, moisture.
Decomposition
Nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Health.
Exposure effects
With therapeutic use - pain at the injection site was a frequent complaint in patients given the drug IM.
   Skin
Bacitracin has been reported to have a low sensitizing potential but has still caused allergic contact dermatitis, eczema, and histamine wheal and flare.

First aid
 
   Ingestion
Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.

Transport.