Barbital

  • Hypnogene
  • Ethylbarbital
  • Veronal acetate
  • 5,5-Diethylbarbituric acid
  • 5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
  • 5,5-Diethylhexahydropyrimidine-2,4,6-trione
Formula
C8H12N2O3
Structure
Description
odorless white solid
Uses
Used as a sedative and hypnotic.

Registry Numbers and Inventories.
CAS
57-44-3
EC (EINECS/ELINCS)
200-331-2
EC Class
harmful
S 22 24/25
RTECS
CQ3500000
RTECS class
Drug; Mutagen
Merck
12,989
Beilstein/Gmelin
163999
Beilstein Reference
5-24-09-00137
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C8H12N2O3
Formula mass
184.20
Melting point, °C
190
Density
1.2 g/cm3 (20 C)
Solubility in water
Slightly soluble
Refractive index
1.4584
pKa/pKb
7.95 (pKa)
Partition coefficient, pKow
0.69
Heat of fusion
24.4 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place.
Handling
Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
Not available. May cause sedation, hypnosis, and coma. Has been implicated in the development of aplastic anemia. Ingestion causes psychological effects in
   Inhalation
Dust is irritating to the respiratory tract.
   Skin
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
HS Code
2933 53 10