Bendroflumethiazide

  • Benzylrodiuran
  • Aprinox
  • Neonaclex
  • 6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro 1,2,4-benzothiadiazine, 1,1-dioxide
  • 3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
Formula
C15H14F3N3O4S2
Structure
Uses
Major uses include medication, therap cat: diuretic, antihypertensive.

Registry Numbers and Inventories.
CAS
73-48-3
EC (EINECS/ELINCS)
200-800-1
RTECS
DK8225000
RTECS class
Drug; Mutagen; Human Data
Merck
12,1064
Beilstein/Gmelin
373316
Beilstein Reference
4-27-00-08041
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C15H14F3N3O4S2
Formula mass
421.42
Boiling point, °C
602
Vapor pressure, mmHg
2E-14 (25 C)
Solubility in water
Insoluble
pKa/pKb
8.63 (pKa)
Heat of vaporization
89.6 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable att normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide. Nitrogen oxides.

Fire.
Flash Point,°C
318
Fire fighting
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.

Health.
Exposure effects
Target organ - kidney. May be harmful by inhalation, ingestion, or skin absorption. May cause irritation. Sensitization: May cause hypersensitivity reactions, hypophosphatemia, purpura, dermatitis with photosensitivity, depression of formed elements of blood, necrotizing vasculitis, exacerbation of renal and/or heptic insufficiency, disturbance in carbohydrate metabolism, pancreatitis. Peripheral Nerve and Sensation:Spastic paralysis with or without sensory change. Behavioral:Convulsions or effect on seizure threshold. Lungs, Thorax, or Respiration:Other changes.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.