Benzidine

  • 4,4'-Diaminobiphenyl
  • p-Diaminodiphenyl
  • (1,1'-Biphenyl)-4,4'-diamine
Formula
C12H12N2
Structure
Description
A grayish-yellow to grayish-red, crystalline solid.
Uses
Manufacture of dyes, as reagent for hydrogen peroxide in milk.

Registry Numbers and Inventories.
CAS
92-87-5
EC (EINECS/ELINCS)
202-199-1
EC Index Number
612-042-00-2
EC Class
Carcinogenic Category 1; Harmful; Dangerous for the Environment
RTECS
DC9625000
RTECS class
Tumorigen; Mutagen; Human Data
UN (DOT)
1885
Merck
12,1106
Beilstein/Gmelin
742770
Beilstein Reference
4-13-00-00364
RCRA
U021
Swiss Giftliste 1
G-1224
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C12H12N2
Formula mass
184.24
Melting point, °C
126 - 127
Boiling point, °C
359
Vapor pressure, mmHg
2.5E-5 (25 C)
Vapor density (air=1)
6.36
Critical temperature
659.8
Critical pressure
32.6
Density
1.251 g/cm3
Solubility in water
400 mg/L
pKa/pKb
9.30 (pKb)
Partition coefficient, pKow
1.34
Heat of fusion
19.1 kJ/mol
Heat of vaporization
60.4 kJ/mol
Heat of combustion
-6535 kJ/mol

Hazards and Protection.
Storage
For cargo ships or passenger ships which are carrying not more than 25 passengers or 1 per 3 m of length, store on deck or under deck.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.
Stability
Darkens on exposure to air and light.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Decomposition
Dangerous when heated to decomposition, emits highly toxic fumes of nitrogen oxides.

Fire.
Flash Point,°C
203
Fire fighting
Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide.
Fire potential
Combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Contain highly toxic NOx fumes.

Health.
Exposure limit(s)
TLV: ppm; mg/m3 A1 (confirmed human carcinogen) (ACGIH 1994-1995). OSHA PEL: 1910.1010 See Appendix B See Appendix C NIOSH REL: Ca See Appendix A See Appendix C NIOSH IDLH: Potential occupational carcinogen
Carcinogin
O, G-A1, I-1, N-1, CP65
Poison_Class
1*
Exposure effects
CNS effects include headache, dizziness, altered mental status, confusion (lethargy progressing coma), seizures, syncope; occur secondary to CNS hypoxia, usually with levels > 20%.
   Ingestion
Nausea and vomiting may occur.
   Inhalation
Dyspnea and tachypnea may occur.
   Skin
Central cyanosis unresponsive to oxygen therapy is classic.
   Eyes
See Inhalation.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
1885
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
BZI
 
Std. Transport #
4921503