Benzthiazide

  • Urese
  • Dihydrex
  • Proaqua
  • 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
  • 3-Benzylthiomethyl-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
  • 3-[(Benzylthio)methyl]-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Formula
C15H14ClN3O4S3
Structure
Uses
Diuretic, antihypertensive medication.

Registry Numbers and Inventories.
CAS
91-33-8
EC (EINECS/ELINCS)
202-061-0
RTECS
DK8400000
RTECS class
Drug
Merck
12,1155
Beilstein/Gmelin
722681
Beilstein Reference
6-27

Properties.
Formula
C15H14ClN3O4S3
Formula mass
431.94
Melting point, °C
236 - 237
Boiling point, °C
658
Vapor pressure, mmHg
3E-17 (25 C)
Solubility in water
67 mg/L (25 C)
pKa/pKb
9.15 (pKa)
Heat of vaporization
96.9 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Flash Point,°C
352
Fire fighting
Extinguish using Noncombustible. Use extinguishing media appropriate to surrounding fire conditions. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.