Berberine sulfate

  • Berberine sulfate (2:1)
  • Berberin sulfate
  • Neutral berberine sulfate
Formula
(C20H18NO4)2.SO4
Structure
Description
Yellow crystals.
Uses
Medication.

Registry Numbers and Inventories.
CAS
316-41-6
EC (EINECS/ELINCS)
206-258-2
RTECS
DR9867300
RTECS class
Drug
Beilstein/Gmelin
NA
Japan ENCS (MITI)
Listed

Properties.
Formula
C20H18NO4.1/2O4S
Formula mass
768.84

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Berberine has both central CNS depressant action and a weak local anesthetic action.
   Ingestion
Berberine is a smooth muscle stimulant which causes stimulation of intestinal peristalsis and bile secretions.
   Inhalation
Respiratory depression has been seen with very large doses in animal experimentation.
   Skin
Pain, hyperpigmentation, flushing, and dermatitis have all been seen after dermal exposure or infiltration of berberine.

First aid
 
   Ingestion
Administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Emesis: ipecac-induced vomiting is not recommended because of the potential for cns depression. All other treatment is symptomatic and supportive.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.