Biodribin

  • 2-CdA
  • 2-Chlorodeoxyadenosine
  • 2-Chloro-2'-deoxyadenosine
  • Cladribine
  • Leustatin
  • 2-Chloro-6-amino-9-(2-deoxy-b-D-erythro-pentofuranosyl)purine
Formula
C10H12ClN5O3
Structure
Description
White solid.

Registry Numbers and Inventories.
CAS
4291-63-8
R: 20/21/22 36/37/38 40
S: 22 24/25 26 36/37/39 45
RTECS
AU7357560
Merck
12,2397
Beilstein/Gmelin
624220

Properties.
Formula
C10H12ClN5O3
Formula mass
285.69
Melting point, °C
220
Vapor pressure, mmHg
4.0E-15 (25 C)
Density
2.03 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
12.41 (pKb)
Partition coefficient, pKow
0.02

Hazards and Protection.
Storage
Keep container tightly closed, in a cool, well-ventilated area. Do not store above 4 C.
Protection
Impervious gloves, chemical safety goggles, lab coat.
Small spills/leaks
Use appropriate tools to put the spilled solid into a waste disposal container. Finish cleaning by spreading water on the contaminated surface.
Incompatibilities
Oxidizing agents.

Fire.
Fire potential
May be combustible at high temperature. Extinguish with dry chemical powder, water spray, fog or foam. Do not use water jet. Wear positive pressure SCBA and full turnout gear.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
May be harmful if inhaled, absorbed through the skin or swallowed. May cause irritation of the respiratory tract, eyes and skin. May cause damage to the kidneys, liver, heart, GI tract, eyes, central nervous system. May cause birth defects based on animal data.
   Skin
Hazardous in case of skin contact (irritant, permeator). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.

First aid
 
   Ingestion
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.
   Inhalation
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
   Skin
In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
   Eyes
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.

Transport.