- p-Phenylene bisisothiocyanate
Yellowish-white, crystalline powder. Almost odorless.
Registry Numbers and Inventories.
R 20/21/22 36/37/38 42
S 22 26 36/37/39 45
Drug; Human Data
Melting point, °C
Boiling point, °C
Solubility in water
Partition coefficient, pKow
Hazards and Protection.
Store in a cool, dry place. Keep container closed when not in use.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Clean up spills immediately, using the appropriate protective equipment.
Stable under normal temperatures and pressures.
Reacts readily with amines.
Irritating and toxic fumes and gases.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire.
When heated to decomposition, it emits very toxic fumes of nitrogen oxides and sulfur oxides.
Side effects reported with short-term therapeutic use have been dizziness or giddiness, vertigo, weakness, and headache. Hallucinations may occur. Bitoscanate has been used experimentally in fetal rats to produce a model of infantile obstructive cholangiopathy. Dilatation of the extrahepatic bile ducts with inflammation, and thickening and fibrosis of the extrahepatic bile ducts without dilatation were produced in these fetal rats. <br>No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation. <br>No information about possible male reproductive effects was found in available references.
Side effects reported with short-term therapeutic use have been nausea, vomiting, diarrhea, abdominal pain or discomfort, and loss of appetite.
This material is highly toxic if ingested. It is a central nervous system and gastrointestinal toxin in humans.
An itching sensation over the body was a side effect reported with short-term therapeutic use.
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
USCG CHRIS Code
2930 90 70