Bitoscanate

  • 1,4-Diisothiocyanatobenzene
  • p-Phenylene bisisothiocyanate
  • Phenylene-1,4-diisothiocyanate
Formula
C8H4N2S2
Structure
Description
Yellowish-white, crystalline powder. Almost odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
4044-65-9
EC (EINECS/ELINCS)
223-741-3
R 20/21/22 36/37/38 42
S 22 26 36/37/39 45
RTECS
NX9150000
RTECS class
Drug; Human Data
UN (DOT)
2928
Merck
13,1304
Beilstein/Gmelin
2414340
Beilstein Reference
4-13-00-00174
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed

Properties.
Formula
C8H4N2S2
Formula mass
192.26
Melting point, °C
131
Boiling point, °C
319
Solubility in water
Practically insoluble
Partition coefficient, pKow
2.36

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Reacts readily with amines.
Decomposition
Irritating and toxic fumes and gases.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire.
Hazards
When heated to decomposition, it emits very toxic fumes of nitrogen oxides and sulfur oxides.

Health.
Exposure effects
Side effects reported with short-term therapeutic use have been dizziness or giddiness, vertigo, weakness, and headache. Hallucinations may occur. Bitoscanate has been used experimentally in fetal rats to produce a model of infantile obstructive cholangiopathy. Dilatation of the extrahepatic bile ducts with inflammation, and thickening and fibrosis of the extrahepatic bile ducts without dilatation were produced in these fetal rats. <br>No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation. <br>No information about possible male reproductive effects was found in available references.
   Ingestion
Side effects reported with short-term therapeutic use have been nausea, vomiting, diarrhea, abdominal pain or discomfort, and loss of appetite.
   Inhalation
This material is highly toxic if ingested. It is a central nervous system and gastrointestinal toxin in humans.
   Skin
An itching sensation over the body was a side effect reported with short-term therapeutic use.
   Eyes
See inhalation

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2928
Response guide
USCG CHRIS Code
BTS
 
HS Code
2930 90 70