Blasticidin S

  • 3-(3-Amino-5-(1-methylguanidino)-1-oxopentylamino-6-(4-amino-2-oxo-2,3-dihydro-pyrimidin-1-yl)-2,3-dihydro-(6H)-pyran-2-carboxylic acid
  • D-erythro-Hex-2-enopyranuronic acid, 4-[3-amino-5-(1-methylguanidino)valeramido]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-
  • Bla-S
Formula
C17H26N8O5
Structure
Description
White powder powder.
Uses
Antifungal against rice blast disease in Japan.

Registry Numbers and Inventories.
CAS
2079-00-7
EC Index Number
607-155-00-9
RTECS
EC4900000
RTECS class
Agricultural Chemical and Pesticide; Natural Product
Merck
12,1350
Beilstein/Gmelin
68255
Beilstein Reference
5-25-14-00412
EPA OPP
6326
Swiss Giftliste 1
G-6440
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C17H26N8O5
Formula mass
422.44
Melting point, °C
235 - 236
Solubility in water
Very soluble
pKa/pKb
2.90 (pKa)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C).
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
2
Exposure effects
   Ingestion
May be fatal if swallowed. May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.