Bretylium tosylate

  • (o-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate
  • N-Ethyl-N-(o-bromobenzyl)-N,N-dimethylammonium tosylate
  • Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-, salt with 4-methylbenzenesulfonic acid (1:1)
Formula
C18H24BrNO3S
Structure
Description
White powder.
Uses
Class III antiarrhythmic agent; Competitive inhibitor of acetylcholinesterase.

Registry Numbers and Inventories.
CAS
61-75-6
EC (EINECS/ELINCS)
200-516-8
20/21/22
RTECS
BO9450000
RTECS class
Drug; Human Data
Merck
12,1395
Beilstein/Gmelin
5704709
Beilstein Reference
6-12
Canada DSL/NDSL
DSL
Austrailia AICS
Listed

Properties.
Formula
C18H24BrNO3S
Formula mass
414.36
Density
50 g/L (25 C)

Hazards and Protection.
Protection
Wear respirator, chemical safety goggles, rubber boots, and heavy rubber gloves.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides, Hydrogen bromide gas.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful by inhalation, in contact with skin and if swallowed. Target organ(s): Cardiovascular system.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.