Broxuridine

  • 2'-Deoxy-5-bromouridine
  • 5-BDU
  • Bromodeoxyuridine
  • 5-Bromodeoxyuridine
  • 5-Bromodesoxyuridine
  • 5-Bromo-2-deoxyuridine
Formula
C9H11BrN2O5
Structure
Description
White crystalline powder.
Uses
Makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow.

Registry Numbers and Inventories.
CAS
59-14-3
EC (EINECS/ELINCS)
200-415-9
RTECS
YU7350000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector
Merck
12,10433
Beilstein/Gmelin
30395
Beilstein Reference
4-24-00-01234
Canada DSL/NDSL
DSL
US TSCA
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C9H11BrN2O5
Formula mass
307.1
Melting point, °C
192 - 193
Vapor density (air=1)
10.6
Solubility in water
Slightly soluble
pKa/pKb
7.85 (pKa)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20 C).
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen bromide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.
   Inhalation
May cause respiratory tract irritation. Low hazard for usual industrial handling.
   Skin
May cause skin irritation. May cause erythema, and edema with crusting and scaling.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid if irritation or symptoms occur.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. DO NOT use mouth-to-mouth respiration.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Transport.