Brucine

  • 2,3-Dimethoxystrychnidin-10-one
  • Dimethoxystrychnine
Formula
C23H26N2O4
Structure
Description
Needles from acetone + water. Odorless.
Uses
Denaturant for ethanol, reagent for separating racemic mixtures.

Registry Numbers and Inventories.
CAS
357-57-3
EC (EINECS/ELINCS)
206-614-7
EC Index Number
614-006-00-1
EC Class
Very toxic; Dangerous for the Environment
R 26/28 52/53
S 13 45 61
RTECS
EH8925000
RTECS class
Drug; Natural Product
UN (DOT)
1570
Merck
12,1476
Beilstein/Gmelin
63046
Beilstein Reference
4-27-00-07875
RCRA
P018
Swiss Giftliste 1
G-1309
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C23H26N2O4
Formula mass
394.47
Decomposition point, °C
330
Vapor pressure, mmHg
6E-16 (25 C)
Vapor density (air=1)
13
Odor Threshold Odor threshold Odorless
Density
1.31 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
5.72 (pKb)
Partition coefficient, pKow
1.48
Heat of vaporization
93.7 kJ/mol
Heat of combustion
-2875 kJ/mol

Hazards and Protection.
Storage
Poison room locked.
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Avoid contact with skin and eyes. Do not ingest or inhale. Use only in a chemical fume hood.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
It is combustible though it may require some effort to ignite.
Hazards
Containers may explode when heated.
Combustion products
Toxic oxides of nitrogen may form in fires.
Health
3

Health.
Poison_Class
2
Exposure effects
Rapid heart rate, elevated blood pressure, rapid breathing, and elevated body temperature may be seen. In severe cases, respiratory paralysis (apnea) with low heart rate, abnormally low blood pressure, and cardiac arrest may occur. Seizures - symptoms may occur within 15 minutes and might include agitation, hypertonicity of muscles, opisthotonos, seizures, and painful muscle spasms. The patient usually remains alert throughout the seizures. Auditory, tactile, or visual stimulation may produce a violent motor response. Chief effects are dictated by the most powerful muscle acting on that joint.
   Ingestion
May cause irritation of the digestive tract. Poison by ingestion. May cause tremors and convulsions.
   Inhalation
May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1570
Response guide
Hazard class
6.1
Packing Group
I
 
USCG CHRIS Code
BRU
 
HS Code
2939 99 90
 
Std. Transport #
4921411