Bumetanide

  • Lunetoron
  • 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
  • 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
  • 3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid
Formula
C17H20N2O5S
Structure
Uses
Diauretic that causes a profound increase in urine output by preventing the kidneys from retaining fluid.

Registry Numbers and Inventories.
CAS
28395-03-1
EC (EINECS/ELINCS)
249-004-6
RTECS
DG4910000
RTECS class
Drug
Merck
12,1508
Beilstein/Gmelin
2185351
Beilstein Reference
6-14
Austrailia AICS
Listed

Properties.
Formula
C17H20N2O5S
Formula mass
364.42
Melting point, °C
230 - 231
Boiling point, °C
571
Vapor pressure, mmHg
7E-14 (25 C)
Density
1.38 g/cm3
Solubility in water
Insoluble
pKa/pKb
3.18 (pKa)
Heat of vaporization
90.1 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Acids.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Flash Point,°C
299
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Avoid contact and inhalation. Target organ(s): Kidneys. Ears.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
Causes skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Transport.