Busulfan

  • 1,4-Butanediol dimethanesulfonate
  • Tetramethylene bis[methanesulfonate]
  • Butane-1,4-diyl bis(methanesulfonate)
  • Leucosulfan
  • Sulphabutin
  • Citosulfan
Formula
CH3SO2O(CH2)4OSO2CH
Structure
Description
White crystals or powder.
Uses
Insect sterilant.

Registry Numbers and Inventories.
CAS
55-98-1
EC (EINECS/ELINCS)
200-250-2
RTECS
EK1750000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
2811
Merck
12,1529
Beilstein/Gmelin
1791786
Beilstein Reference
4-04-00-00019
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C6H14O6S2
Formula mass
246.31
Melting point, °C
119
Solubility in water
Soluble
Partition coefficient, pKow
-1.14

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.
Stability
No data.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, oxides of sulfur, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.
Fire potential
This material is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Carcinogin
I-1, N-1, CP65
Exposure effects
   Ingestion
Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Dust is irritating to the respiratory tract. Causes respiratory tract irritation.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation. May cause irreversible eye injury.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III