Butyl isocyanate

  • 1-Isocyanatobutane
Formula
CH3(CH2)3N C O
Structure
Description
Colorless liquid, lachrymator.
Uses
N-butyl isocyanate is used as an intermediate in the production of carbamate and urea insecticides and fungicides and is also used in the manufacture of sulfonyl urea antidiabetic drugs.

Registry Numbers and Inventories.
CAS
111-36-4
EC (EINECS/ELINCS)
203-862-8
EC Class
highly flammable, very toxic, corrosive, sensitizing
R 11 22 26 34 42
S 16 23 26 28 36/37/39 45
RTECS
NQ8250000
RTECS class
Other
UN (DOT)
2485
Merck
13,1574
Beilstein/Gmelin
73917
Beilstein Reference
4-17-00-02559
EPA OPP
600052
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C5H9NO
Formula mass
99.1
Melting point, °C
-75
Boiling point, °C
112
Vapor pressure, mmHg
18 (25 C)
Vapor density (air=1)
3.00
Saturation Concentration
Approx. 14,000 ppm (approx. 1.4%) @ 20 C; approx. 22,400 ppm (approx. 2.24%) @ 24 C (calc)
Density
0.880 g/cm3 (20 C)
Solubility in water
Slightly soluble
Viscosity
4.9729x10-2 @ 193 K
Surface tension
4.9729x10-2 @ 193 K
Refractive index
1.406 (20 C)
Partition coefficient, pKow
2.42
Heat of vaporization
35.3 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep under a nitrogen blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
B2 D1A D2A D2B
Handling
Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Use with adequate ventilation. Do not allow contact with water. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Stability
Stable under normal temperatures and pressures. Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Moisture, strong bases, strong oxidizing agents, strong acids.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
18
Autoignition, °C
425
Upper exp. limit, %
10
Lower exp. limit, %
1.3
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products. Containers may explode in the heat of a fire. Water Reactive. Contact with metals may evolve flammable hydrogen gas. Extinguishing media: For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective.
Fire potential
HIGHLY FLAMMABLE.
Hazards
Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
3
 
 
Reactivity
2
 
 
Special
W

Health.
Exposure effects
Prolonged or repeated exposure may cause nausea, dizziness, and headache. Repeated or prolonged exposure may cause allergic reactions in sensitive individuals.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause headache. May cause nausea and vomiting. May be harmful if swallowed.
   Inhalation
Causes respiratory tract irritation. May cause lung damage. May cause an allergic response. Vapors may cause dizziness or suffocation.
   Skin
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
   Eyes
Causes eye irritation. Lachrymator.

First aid
 
   Ingestion
Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
2485
Response guide
Hazard class
6.1
PRTC
T
Packing Group
I
 
HS Code
2929 10 90
 
Std. Transport #
4927027