Butylate

  • R-1910
  • Aneldazine
  • Butilate
  • Diisocarb
  • S-Ethyl bis(2-Methylpropyl) carbamothioate
  • Ethyl-N,N-diisobutylthiocarbamate
Formula
C11H23NOS
Structure
Description
Colorless liquid. Aromatic odor.
Uses
Herbicide.

Registry Numbers and Inventories.
CAS
2008-41-5
EC (EINECS/ELINCS)
217-916-3
RTECS
EZ7525000
RTECS class
Agricultural Chemical and Pesticide; Mutagen
Merck
12,1581
Beilstein/Gmelin
1770420
Beilstein Reference
4-04-00-00651
RCRA
U392
EPA OPP
41405
Swiss Giftliste 1
G-6498
Canada DSL/NDSL
NDSL
US TSCA
Listed

Properties.
Formula
C11H23NOS
Formula mass
217.38
Boiling point, °C
130
Vapor pressure, mmHg
0.01
Density
0.9296 g/cm3 (30 C)
Solubility in water
45 mg/L @ 22 C
Refractive index
1.4689 (25 C)
Partition coefficient, pKow
4.15

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Safety glasses, goggles, or faceshield; impervious gloves and apron.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Apparently indefinite storage life under normal ambient conditions. Thermally stable up to 200 C. Hydrolyzed by strong acids and bases.

Fire.
Fire fighting
Wear self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode when fighting fire.

Health.
Poison_Class
4
Exposure effects
Exposure to thiram or mbdt-carb (based on animal studies) may cause weakness, ataxia, ascending paralysis and hypothermia. Peripheral neuropathy (pain, numbness and weakness of the extremities) has been noted following exposure to thiuram (the ethyl analog of thiram). No adverse reproductive effects (testicular parameters) in male mice were observed following methyl thiophanate doses up to 1000 mg/kg orally for 5 consecutive days (Traina et al, 1998). Maternal toxicity was evident in female rats.
   Ingestion
Nausea, vomiting and diarrhea may occur.
   Inhalation
Respiratory failure, requiring ventilatory support, has been reported following ingestions.
   Skin
Exposure to dusts, sprays, solutions, wettable powder suspensions or emulsions of these agents may lead to skin and mucous membrane irritation.

First aid
 
   Ingestion
Ipecac induced vomiting is not recommended because of the potential for cns depression and seizures. Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Intravenous fluids may be useful in restoring extracellular fluid volume following severe vomiting and diarrhea. Oxygen therapy is effective in relieving the distress of antabuse-like reactions rarely associated with exposure to thiram and possibly the mbdt-carb compounds. No specific antidotes are available for poisoning by these compounds. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.