beta-Pilocarpine nitrate

  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3R-trans)-, mononitrate
Formula
C11H16N2O2.HNO3
Structure
Description
Very slightly yellow solid.

Registry Numbers and Inventories.
CAS
5984-94-1
EC (EINECS/ELINCS)
227-800-4
UN (DOT)
2811
Beilstein/Gmelin
4171406
Beilstein Reference
4-27-00-07463

Properties.
Formula
C11H16N2O2*HNO3
Formula mass
271.27
Melting point, °C
178

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, silver nitrate, mercury bichloride,iodides, gold salts, tannin, calomel, alkalies, potassium permanganate.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood.
   Inhalation
May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
   Skin
No information regarding skin irritation and other potential effects was found.
   Eyes
No information regarding eye irritation and other potential effects was found.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III