Caffeic acid

  • 3,4-Dihydroxycinnamic acid
  • 3,4-Dihydroxybenzeneacrylic acid
  • 3-(3,4-Dihydroxyphenyl)-2-propenoic acid
  • 4-(2'-Carboxyvinyl)-1,2-dihydroxybenzene
  • 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
Formula
3,4-(OH)2C6H3CH=CHCOOH
Structure
Description
Yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange.
Uses
inhibitor of poly(ethylene glycol) oxidation

Registry Numbers and Inventories.
CAS
331-39-5
EC (EINECS/ELINCS)
206-361-2
EC Class
carcinogenic
R 36/37/38 40
S 22 26 36/37/39
RTECS
GD8950000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Natural Product
Merck
13,1635
Beilstein/Gmelin
2210883
Beilstein Reference
2-10-00-00294
Canada DSL/NDSL
DSL
New Zealand
Listed

Properties.
Formula
C9H8O4
Formula mass
180.16
Melting point, °C
234 - 237
Boiling point, °C
366
Critical temperature
581
Critical pressure
57.3
Solubility in water
Very soluble
pKa/pKb
4.04 (pKa)
Partition coefficient, pKow
1.15

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.
Disposal code
4
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - strong bases.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.

Health.
Carcinogin
I-2B, CP65
Exposure effects
The toxological properties of this substance have not been fully investigated.
   Ingestion
The toxicological properties of this substance have not been fully investigated.
   Inhalation
The toxicological properties of this substance have not been fully investigated.
   Skin
No information regarding skin irritation and other potential effects was found.
   Eyes
May cause eye irritation. No information regarding eye irritation and other potential effects was found.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
4. Organic acids
HS Code
2918 29 90