Cantharidine

  • CAN
  • Cantharides camphor
  • Cantharidin
  • Cantharone
  • Exo-1,2-cis-dimethyl-3,6-Epoxyhexahydrophthalic anhydride
  • 1,2-Dimethyl-3,6-Epoxyperhydrophthalic anhydride
Formula
C10H12O4
Structure
Description
White crystals.
Uses
Used for the removal of warts.

Registry Numbers and Inventories.
CAS
56-25-7
EC (EINECS/ELINCS)
200-263-3
RTECS
RN8575000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Human Data; Natural Product
Merck
12,1797
Beilstein/Gmelin
85302
Beilstein Reference
5-19-05-00051
EPA OPP
13101
Swiss Giftliste 1
G-3965
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed

Properties.
Formula
C10H12O4
Formula mass
196.2
Melting point, °C
217
Sublimation point, °C
84
Density
1.41 g/cm3
Solubility in water
insoluble in cold water

Hazards and Protection.
Storage
Keep in a sealed container. Place in a poison cabinet with controlled access.
Handling
Do not open container without reading the MSDS. This material is very expensive, costing about $500,000 for less than 100 mg. Always handle while while using protective equipment. Always use in a chemical fume hood. This material is a very, very toxic material.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Dust mask.
Small spills/leaks
Wearing protective equipment, swap up small quantites with a pad moistened with a mild alkali. Collect and transfer the swabs for waste disposal. Clean surfaces with a solution of sodium hydroxide.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Very toxic fumes.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Hazards
When heated to decomposition it emits acrid smoke and irritating fumes.

Health.
Poison_Class
1
Exposure effects
Abnormally low blood pressure may develop with severe poisonings. Heart rate and respiration may be initially stimulated and then depressed. Neurologic effects include delirium, syncope, ataxia, coma, and occasionally seizures and flaccid paralysis.
   Ingestion
Extremely poisonous.
   Inhalation
Dangerous to respiratory tract.
   Skin
Mild to severe reactions may be seen. Cantharidin is a vesicant and may cause blisters within 4 to 5 hours of application. Acantholysis may be seen. Cantharidin has been used in vivo to induce acantholysis.
   Eyes
Inflammation of the eye, keratitis, iritis, and edema of the lids has been noted. A burning sensation of the mouth and throat after ingestion is common. Swelling and blistering of the tongue may be seen.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
USCG CHRIS Code
CRD