Capreomycin

  • Capastat
  • Capostatin
  • Capromycin
  • Kapreomycin
Formula
C25H44N14O8
Description
Odorless, white solid.
Uses
Antibiotic.

Registry Numbers and Inventories.
CAS
11003-38-6
RTECS
EX8920000
RTECS class
Drug; Human Data
Beilstein/Gmelin
6468539
Beilstein Reference
6-26

Properties.
Formula
C25H44N14O8
Formula mass
668.71
Solubility in water
Freely soluble

Hazards and Protection.
Storage
Store in a cool, dry location.
Incompatibilities
Avoid contact with acids and bases.

Fire.

Health.
Exposure effects
With therapeutic use, capreomycin is toxic to the kidneys, the ear, and the eye. Electrolyte abnormalities and metabolic alkalosis may occur with therapeutic use. Leukocytosis eosinophilia, and various skin rashes may occur. Respiratory paralysis may occur.

First aid
 
   Ingestion
There is no specific antidote for this injectable drug Treatment is symptomatic and supportive. If renal damage is significant, hemodialysis may be indicated. It is poorly absorbed after ingestion, toxicity is unlikely Consider gastrointestinal decontamination only after very large ingestions. Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.
   Eyes
Irrigate eye for at least 20 minutes with water or saline. If irritation persists, seek medical attention.

Transport.